Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%

Top Medical Research Studies

9.5
We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
Read More
9
Selenium nanoparticles aid heart recovery
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.

Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.

In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
Read More
2
Vitamin E links to heart risks
We explored the relationship between vitamin E and heart attack risk through a two-sample mendelian randomization study. Using genetic variations from nearly 8,000 individuals of European descent, we dug into whether higher levels of vitamin E could protect against coronary artery disease (CAD) and myocardial infarction (MI).

Contrary to some previous beliefs about its benefits, our results suggested that increased vitamin E levels were actually associated with a higher risk of both CAD and MI. This means it's time to rethink the safety and effectiveness of vitamin E supplements for heart health.
Read More

Most Useful Reviews

9
Improved energy levels
4 people found this helpful
The complex is effective! I began taking it on the advice of a nutritionist to restore my thyroid function, addressing fatigue, muscle weakness, and heart issues. Almost immediately, I felt better; my energy increased, hair loss decreased, and my heartbeat was more stable. I recommend this essential vitamin for optimal body performance. Please like if you find this helpful.
Read More
9
Improved heart function
1 people found this helpful
Selenium is vital for health; it aids iron and iodine absorption, boosts immunity, and lowers heart attack risks while improving blood pressure. I took it regularly and felt more energetic and rejuvenated. The capsules are easy to take in the morning before meals. Please like if this helped!
Read More
9
Avoided hormone therapy
1 people found this helpful
I avoided hormone therapy thanks to this product. I felt constantly tired with heart arrhythmia last year, but this selenium product has been life-changing. I definitely don't want to go without it.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
  • All Researches
9.5
We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.
Read More
9
Selenium nanoparticles aid heart recovery
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.

Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.

In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
Read More
9
Selenium's potential in cardiac recovery
We investigated how selenium, specifically in the form of selenium nanoparticles (Se NPs), can play a role in recovering from heart attacks. Our study focused on developing a unique hydrogel that combines Se NPs with a polymer base to improve cardiac repair after acute myocardial infarction (MI).

We explored the effects of the Se NPs on human heart cells and conducted experiments on mice models. The results were promising; the hearts of the treated mice showed a significant improvement with the left ventricular wall thickness increasing from a mere 235.6 micrometers to an impressive 390 micrometers.

Not only did these treatments help thicken the heart walls, but we also saw a remarkable reduction in scar thickness and infarct size when compared to control groups. This suggests that our selenium-infused hydrogel could be a valuable solution to promote heart healing post-MI, paving the way for potentially advanced treatments in the future.
Read More
9
Gold nanocages help heart recovery
We explored the potential of a novel treatment involving L-arginine-loaded gold nanocages designed to help with heart attack recovery. This innovative approach aims to tackle the problem of myocardial ischemia/reperfusion injury, a condition that can cause additional damage to the heart after blood flow is restored post-heart attack.

The gold nanocages in this study were enhanced with selenium and targeted towards heart cells, allowing for better absorption and effectiveness. Our tests showed that this treatment reduced cell damage and improved cell health during oxygen and glucose deprivation, which is crucial during heart attacks.

Furthermore, we observed that this treatment can help maintain mitochondrial function, leading to better energy production in heart cells. By preventing harmful oxidative reactions, it helps preserve nitric oxide, a vital molecule that supports heart health.

Ultimately, the results indicated that this approach could improve overall heart function and reduce cell death in heart tissue. The findings are promising and suggest a new pathway for effective heart attack treatments while ensuring safe and biocompatible use in living organisms.
Read More
We explored an innovative approach to treating heart attacks, specifically looking at how selenium can make a difference. Our study focused on a special injectable hydrogel made from a combination of selenium, polypropylene glycol, and polyethylene glycol. The goal was to see if this formulation could help reduce inflammation and fibrosis after a myocardial infarction (heart attack).

We conducted our research on a mouse model of myocardial infarction, observing the effects of our selenium-containing hydrogel. The results were promising—our formulation demonstrated the ability to promote recovery in heart function. Through various tests, including enzyme-linked immunosorbent assays and tissue analysis, we confirmed that the gel effectively inhibits harmful inflammation and fibrosis that often occur after a heart attack.

Overall, this work highlights the potential of selenium as a beneficial component in therapies for heart attacks and possibly other inflammatory conditions. Our findings suggest that a selenium-infused polymeric hydrogel could be an effective strategy for improving heart health in the aftermath of a myocardial infarction.
Read More

User Reviews

USERS' SCORE
Good
Based on 9 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Improved energy levels
4 people found this helpful
The complex is effective! I began taking it on the advice of a nutritionist to restore my thyroid function, addressing fatigue, muscle weakness, and heart issues. Almost immediately, I felt better; my energy increased, hair loss decreased, and my heartbeat was more stable. I recommend this essential vitamin for optimal body performance. Please like if you find this helpful.
Read More
9
Improved heart function
1 people found this helpful
Selenium is vital for health; it aids iron and iodine absorption, boosts immunity, and lowers heart attack risks while improving blood pressure. I took it regularly and felt more energetic and rejuvenated. The capsules are easy to take in the morning before meals. Please like if this helped!
Read More
9
Avoided hormone therapy
1 people found this helpful
I avoided hormone therapy thanks to this product. I felt constantly tired with heart arrhythmia last year, but this selenium product has been life-changing. I definitely don't want to go without it.
Read More
7.5
Promotes cardiovascular health
1 people found this helpful
Excellent! Selenium-rich foods enhance cardiovascular health, acting as an anti-inflammatory and improving blood flow. Studies suggest selenium reduces the risk of heart disease and combats atherosclerosis.
Read More
7.5
Enhanced physical activity
1 people found this helpful
I found significant benefits from this supplement. It boosted my physical activity and decreased fatigue due to thyroid issues, contributing to better overall health and heart function.
Read More

Frequently Asked Questions

9
Improved energy levels
4 people found this helpful
The complex is effective! I began taking it on the advice of a nutritionist to restore my thyroid function, addressing fatigue, muscle weakness, and heart issues. Almost immediately, I felt better; my energy increased, hair loss decreased, and my heartbeat was more stable. I recommend this essential vitamin for optimal body performance. Please like if you find this helpful.
9
Improved heart function
1 people found this helpful
Selenium is vital for health; it aids iron and iodine absorption, boosts immunity, and lowers heart attack risks while improving blood pressure. I took it regularly and felt more energetic and rejuvenated. The capsules are easy to take in the morning before meals. Please like if this helped!
9
Avoided hormone therapy
1 people found this helpful
I avoided hormone therapy thanks to this product. I felt constantly tired with heart arrhythmia last year, but this selenium product has been life-changing. I definitely don't want to go without it.
7.5
Enhanced physical activity
1 people found this helpful
I found significant benefits from this supplement. It boosted my physical activity and decreased fatigue due to thyroid issues, contributing to better overall health and heart function.
6
Normalised metabolism
Selenium is essential for those with arrhythmia and heart disease. It normalises fat metabolism and cholesterol, protecting my heart and reducing my risk of heart attack.
7.5
Promotes cardiovascular health
1 people found this helpful
Excellent! Selenium-rich foods enhance cardiovascular health, acting as an anti-inflammatory and improving blood flow. Studies suggest selenium reduces the risk of heart disease and combats atherosclerosis.
7.5
Enhanced cellular immunity
20 people found this helpful
Selenium is crucial for immune function and fat metabolism, lowering heart attack risks while improving blood pressure. I feel more energetic and rejuvenated. I take the capsules in the morning before meals. Please like if this was helpful!
6
Convenient supplement
Selenium is essential for heart disease and recovery post-heart attack. It normalises fat metabolism and cholesterol, protecting my heart. The capsules are small, convenient, and effective.
9
Selenium nanoparticles aid heart recovery
We investigated the potential of spherical selenium nanoparticles (SeNPs) to reduce the harmful effects of ischemia/reperfusion injury (I/RI) that often occurs after a heart attack. The study involved intravenous injections of these nanoparticles, which showcased impressive antioxidant and anti-inflammatory properties.

Our findings revealed that SeNPs effectively disrupted the harmful cycle of oxidative stress and inflammation associated with heart damage. They helped protect the heart cells by keeping mitochondrial functions intact and reducing programmed cell death, also known as apoptosis. Furthermore, SeNPs managed to lessen the invasion of inflammatory cells and reduce the release of harmful mediators during I/RI.

In practical terms, when tested in vivo, the selenium nanoparticles significantly improved heart function while reducing both cell death and tissue scarring. This indicates that these nanoparticles could offer a promising new approach to enhance treatments following heart attacks, specifically by focusing on the key pathway of STAT1, which plays a crucial role in mediating injury and inflammation.
We explored the effects of selenium (Se) on heart health, specifically its ability to promote healing after a heart attack, also known as myocardial infarction (MI). Our research was conducted using a rat model where we induced heart attacks using a chemical agent called isoprenaline (ISP). After one week, we administered selenium either by itself or combined with another treatment, pentoxifylline (PTXF).

We found that selenium, both alone and with PTXF, showed promising potential in reducing damage caused by heart attacks. The treatment led to improvements in heart function indicators and enhanced angiogenesis, which is the formation of new blood vessels—critical for healing. Importantly, the combination of selenium and PTXF was more effective than using either treatment separately.

Our study highlights the beneficial effects of selenium on cardiac health and suggests a new avenue for treatment strategies following heart attacks. These results point to selenium, especially combined with PTXF, as a potentially impactful option for further investigation in clinical settings.
A recent case-control study within the PREDIMED trial aimed to find out if low selenium levels might increase the risk of heart attacks and other cardiovascular events. We focused on a group of 207 participants who had experienced significant cardiovascular events, such as heart attacks or strokes, and compared them to 436 controls that matched in sex, age, and intervention group.

The findings revealed that women with a heart condition had lower selenium levels compared to those without, suggesting a possible link between selenium deficiency and heart health. Interestingly, we discovered that, across all participants, there was an inverse relationship between selenium levels and cardiovascular risk. In fact, those with higher selenium concentrations experienced a reduced risk for their first cardiovascular event, highlighting the mineral's potential protective role.

While compared to dietary habits, selenium levels were found to be influenced by factors such as protein and fish intake, as well as age and body mass index. This connection indicates that a well-rounded diet might enhance selenium levels, potentially bolstering heart health.

Ultimately, though we found some positive associations between selenium levels and cardiovascular risk, it’s essential to note the varying factors at play, especially given that lifestyle and diet also play a significant role in cardiovascular health.

References

  1. Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. 10.1016/j.biomaterials.2025.123119
  2. Elseweidy MM, Ali SI, Shaheen MA, Abdelghafour AM, Hammad SK. Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4677. 10.1007/s00210-023-02904-9
  3. Sun Q, Yao J, Zhang Z, Li J, Zhang X, et al. Facile fabrication of biocompatible injectable blended polymeric hydrogel with bioactive nanoformulation to improving cardiac tissue regeneration efficiency after myocardial infarction for nursing care potential applications. Nanotoxicology. 2023;17:432. 10.1080/17435390.2023.2252921
  4. Wang Z, Yang N, Hou Y, Li Y, Yin C, et al. L-Arginine-Loaded Gold Nanocages Ameliorate Myocardial Ischemia/Reperfusion Injury by Promoting Nitric Oxide Production and Maintaining Mitochondrial Function. Adv Sci (Weinh). 2023;10:e2302123. 10.1002/advs.202302123
  5. Sun Q, Ma H, Zhang J, You B, Gong X, et al. A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction. Adv Sci (Weinh). 2023;10:e2204999. 10.1002/advs.202204999
  6. Gutiérrez-Bedmar M, Gil F, Olmedo P, Ruiz-Canela M, Martínez-González MÁ, et al. Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study. J Clin Med. 2022;11. 10.3390/jcm11226664
  7. Yang C, Zhu C, Li Y, Li Z, Zhang Z, et al. Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction. Front Bioeng Biotechnol. 2022;10:912562. 10.3389/fbioe.2022.912562
  8. Filonenko M, Zhuravlyova L, Sokolnikova N. CORRELATION OF CARDIAC BIOMARKERS WITH THE LEVELS OF SELENIUM AND ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND A HISTORY OF HYPERTENSION. Wiad Lek. 2022;75:362.
  9. Frączek-Jucha M, Kabat M, Szlósarczyk B, Czubek U, Nessler J, et al. Selenium deficiency and the dynamics of changes of thyroid profile in patients with acute myocardial infarction and chronic heart failure. Kardiol Pol. 2019;77:674. 10.33963/KP.14822
  10. Büttner P, Obradovic D, Wunderlich S, Feistritzer HJ, Holzwirth E, et al. Selenoprotein P in Myocardial Infarction With Cardiogenic Shock. Shock. 2020;53:58. 10.1097/SHK.0000000000001342
  11. Khaki-Khatibi F, Mansouri F, Hajahmadipoorrafsanjani M, Ghojazadeh M, Gholikhani-Darbroud R. Study of rs1137101 polymorphism of leptin receptor gene with serum levels of selenium and copper in the patients of non-ST-segment elevation myocardial infarction (NSTEMI) in an Iranian population. Clin Biochem. 2018;60:64. 10.1016/j.clinbiochem.2018.06.016
  12. Dallak M. A synergistic protective effect of selenium and taurine against experimentally induced myocardial infarction in rats. Arch Physiol Biochem. 2017;123:344. 10.1080/13813455.2017.1347687
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  15. Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. 10.1016/j.freeradbiomed.2025.03.004
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  20. Zhang F, Zhang Y, Qian S, Qian X, Jiao J, et al. Injectable and Conductive Nanomicelle Hydrogel with α-Tocopherol Encapsulation for Enhanced Myocardial Infarction Repair. ACS Nano. 2024;18:10216. 10.1021/acsnano.4c00509
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  23. Loffredo L, Perri L, Di Castelnuovo A, Iacoviello L, De Gaetano G, et al. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis. Nutr Metab Cardiovasc Dis. 2015;25:354. 10.1016/j.numecd.2015.01.008
  24. Shukla SK, Sharma SB, Singh UR. Pre-treatment with α-tocopherol and Terminalia arjuna ameliorates, pro-inflammatory cytokines, cardiac and apoptotic markers in myocardial infracted rats. Redox Rep. 2015;20:49. 10.1179/1351000214Y.0000000104
  25. Rodrigo R, Hasson D, Prieto JC, Dussaillant G, Ramos C, et al. The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial. Trials. 2014;15:192. 10.1186/1745-6215-15-192
  26. Vardi M, Blum S, Levy AP. Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus - natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature. Eur J Intern Med. 2012;23:628. 10.1016/j.ejim.2012.04.009
  27. Rautiainen S, Akesson A, Levitan EB, Morgenstern R, Mittleman MA, et al. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr. 2010;92:1251. 10.3945/ajcn.2010.29371
  28. Blum S, Vardi M, Brown JB, Russell A, Milman U, et al. Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. Pharmacogenomics. 2010;11:675. 10.2217/pgs.10.17
  29. Punithavathi VR, Prince PS. Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Life Sci. 2010;86:178. 10.1016/j.lfs.2009.11.021
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